UniProt Accession

 TM55B_HUMAN; Q86T03; B2RA35; Q86U09; Q8WUC0; Q9BU67; Q9NSU8 

Genbank Protein ID

 BX161490; BX248025; AK314021; AL137727; CH471078; BC002867; BC020947 

Genbank Nucleotide ID

 CAD61939.1; CAD62347.1; BAG36732.1; CAB70896.1; EAW66461.1; AAH02867.2; AAH20947.1 

Protein Name

 Transmembrane protein 55B 

Protein Synonyms/Alias

 PtdIns-4,5-P2 4-Ptase I; Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase 

Gene Name

 TMEM55B 

Gene Synonyms/Alias

 C14orf9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	SLINVEGKMHQHVVK	ubiquitination	[1, 2]
155	ACPRPYCKRIINLGP	ubiquitination	[2]
185	RVICGHCKNTFLWTE	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. 

Sequence Annotation

 MOTIF 133 139 CX5R motif.
 ACT_SITE 133 133 By similarity.
 MOD_RES 162 162 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Endosome; Hydrolase; Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 

Interpro

 IPR019178; Transmembrane_protein_55A/B. 

Pfam

 PF09788; Tmemb_55A 

SMART

  

PROSITE

  

PRINTS