UniProt Accession

 TADA3_MOUSE; Q8R0L9; Q8CIH4; Q8K289; Q8R5E3; Q9CTJ0 

Genbank Protein ID

 AF383154; AK003405; AK078906; BC022707; BC023879; BC026630; BC032195 

Genbank Nucleotide ID

 AAM21463.1; BAB22769.1; BAC37451.1; AAH22707.1; AAH23879.1; AAH26630.1; AAH32195.1 

Protein Name

 Transcriptional adapter 3 

Protein Synonyms/Alias

 ADA3 homolog; mADA3; Transcriptional adapter 3-like; ADA3-like protein 

Gene Name

 Tada3 

Gene Synonyms/Alias

 Ada3; Tada3l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
109	KKQKLEGKTGHGPGP	acetylation	[1]
418	KEKDQAWKTLKERES	acetylation	[1, 2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). 

Sequence Annotation

 MOD_RES 418 418 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:MGI.
 GO:0072686; C:mitotic spindle; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0030914; C:STAGA complex; IDA:MGI.
 GO:0033276; C:transcription factor TFTC complex; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; IEA:Compara.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0007067; P:mitosis; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0031063; P:regulation of histone deacetylation; IGI:MGI.
 GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
 GO:0031647; P:regulation of protein stability; IMP:MGI.
 GO:0090043; P:regulation of tubulin deacetylation; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR019340; Histone_AcTrfase_su3. 

Pfam

 PF10198; Ada3 

SMART

  

PROSITE

  

PRINTS