CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021114
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 22 
Protein Synonyms/Alias
 Zinc finger protein Krox-25 
Gene Name
 Znf22 
Gene Synonyms/Alias
 Krox25; Zfp422 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
18SRSASQGKTYESKRKacetylation[1]
74SSTLFQHKKIHTGKKacetylation[1]
217WKRGKGRKAVAGLRQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). 
Sequence Annotation
 ZN_FING 55 82 C2H2-type 1.
 ZN_FING 83 110 C2H2-type 2.
 ZN_FING 111 138 C2H2-type 3.
 ZN_FING 139 166 C2H2-type 4.
 ZN_FING 167 194 C2H2-type 5.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MRLGKPKGGI SRSASQGKTY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV DEKPYKCTKC 60
SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGERF 120
KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS 180
HLRQHMKVHK EKKSHKRGKN ARAKTHPVSW KRGKGRKAVA GLRQVKGAAS GLFKKKK 237 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042476; P:odontogenesis; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS