UniProt Accession

 BRD7_HUMAN; Q9NPI1; Q4VC09; Q8N2L9; Q96KA4; Q9BV48; Q9UH59 

Genbank Protein ID

 AF213969; AJ271881; AF152604; BC001611; AC007493; AC007597; AC023826; BC050728; BC094706; AK027308; AK074613 

Genbank Nucleotide ID

 AAF19526.1; CAB72445.1; AAF75126.1; AAH01611.1; AAH50728.1; AAH94706.1; BAB55031.1; BAC11089.1 

Protein Name

 Bromodomain-containing protein 7 

Protein Synonyms/Alias

 75 kDa bromodomain protein; Protein CELTIX-1 

Gene Name

 BRD7 

Gene Synonyms/Alias

 BP75; CELTIX1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	LYEEYVEKPLKLVLK	acetylation	[1, 2]
21	LYEEYVEKPLKLVLK	ubiquitination	[3]
186	STMKEKIKNNDYQSI	ubiquitination	[3]
305	DKDMLEDKFKSNNLE	ubiquitination	[3]
328	IVKESGGKLTRRLVN	acetylation	[4]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. 

Sequence Annotation

 DOMAIN 148 218 Bromo.
 MOTIF 65 96 Nuclear localization signal.
 MOD_RES 279 279 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Bromodomain; Cell cycle; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 651 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0070577; F:histone acetyl-lysine binding; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0035066; P:positive regulation of histone acetylation; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR001487; Bromodomain.
 IPR021900; DUF3512. 

Pfam

 PF00439; Bromodomain
 PF12024; DUF3512 

SMART

 SM00297; BROMO 

PROSITE

 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2 

PRINTS

 PR00503; BROMODOMAIN.