CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 18 
Protein Synonyms/Alias
  
Gene Name
 LRRC18 
Gene Synonyms/Alias
 UNQ9338/PRO34010 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
170ISKLPKLKKLNIKRNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in the regulation of spermatogenesis and sperm maturation (By similarity). 
Sequence Annotation
 REPEAT 28 49 LRR 1.
 REPEAT 51 72 LRR 2.
 REPEAT 74 95 LRR 3.
 REPEAT 97 118 LRR 4.
 REPEAT 122 144 LRR 5.
 REPEAT 145 167 LRR 6.
 REPEAT 168 189 LRR 7.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MVKGEKGPKG KKITLKVARN CIKITFDGKK RLDLSKMGIT TFPKCILRLS DMDELDLSRN 60
LIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLY LNVSNNRLTS NGLPVELKQL 120
KNIRAVNLGL NHLDSVPTTL GALKELHEVG LHDNLLNNIP VSISKLPKLK KLNIKRNPFP 180
KPGESEIFID SIRRLENLYV VEEKDLCAAC LRKCQNARDN LNRIKNMATT TPRKTIFPNL 240
ISPNSMAKDS WEDWRIRLTS S 261 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 
Pfam
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
  
PROSITE
 PS51450; LRR 
PRINTS