UniProt Accession

 1B53_HUMAN; P30491; O78053; O78138; Q30198; Q5TK76; Q9BD43; Q9GJF0; Q9MY42; Q9TP36; Q9TQH8 

Genbank Protein ID

 M58636; U90566; AJ311599; AH003636; AH006439; AH008879; AH007566; AH010237; AJ276996; AJ293856; AJ293857 

Genbank Nucleotide ID

 AAA36228.1; AAB96793.1; CAC35317.1; AAB05926.1; AAC35939.1; AAF20814.1; AAD23461.1; AAG53942.1; CAB86197.1; CAC05305.1; CAC05305.1 

Protein Name

 HLA class I histocompatibility antigen, B-53 alpha chain 

Protein Synonyms/Alias

 Bw-53; MHC class I antigen B*53 

Gene Name

 HLA-B 

Gene Synonyms/Alias

 HLAB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	DRNTQIFKTNTQTYR	ubiquitination	[1]
200	RRYLENGKETLQRAD	ubiquitination	[1]
210	LQRADPPKTHVTHHP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 209 295 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 308 Connecting peptide.
 CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
 DISULFID 125 188
 DISULFID 227 283  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.