UniProt Accession

 SLAF6_HUMAN; Q96DU3; A6NMW2; B2R8X8; Q14CF0; Q5TAS4; Q5TAS6; Q5TAT3; Q96DV0 

Genbank Protein ID

 AJ277141; AJ306388; AY358159; AL832854; AK125624; AK301026; AK313549; AL138930; AL138930; AL138930; CH471121; CH471121; BC113893; BC114495 

Genbank Nucleotide ID

 CAC59749.1; CAC59750.1; AAQ88526.1; CAI46161.1; BAG54223.1; BAG62642.1; BAG36325.1; CAI15155.1; CAI15156.1; CAI15157.1; EAW52713.1; EAW52715.1; AAI13894.1; AAI14496.1 

Protein Name

 SLAM family member 6 

Protein Synonyms/Alias

 Activating NK receptor; NK-T-B-antigen; NTB-A; CD352 

Gene Name

 SLAMF6 

Gene Synonyms/Alias

 KALI; UNQ6123/PRO20080 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
319	INHSKESKPTFSRAT	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 

Sequence Annotation

 DOMAIN 132 209 Ig-like.
 MOD_RES 274 274 Phosphotyrosine.
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 309 309 Phosphotyrosine.
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 171 171 N-linked (GlcNAc...); atypical.
 CARBOHYD 178 178 N-linked (GlcNAc...).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 DISULFID 147 214
 DISULFID 153 195  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004872; F:receptor activity; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR015631; SLAM_fam_rcpts. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS