UniProt Accession

 TYY2_HUMAN; O15391; B2RP10; Q6Q1S4 

Genbank Protein ID

 AY567472; AK091850; U73479; CH471074; BC137215; BC137217 

Genbank Nucleotide ID

 AAS68634.1; BAG52427.1; AAD08633.1; EAW98983.1; AAI37216.1; AAI37218.1 

Protein Name

 Transcription factor YY2 

Protein Synonyms/Alias

 Yin and yang 2; YY-2; Zinc finger protein 631 

Gene Name

 YY2 

Gene Synonyms/Alias

 ZNF631 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
218	SEYLKGKKLPPGGLP	ubiquitination	[1]
309	QLVHTGEKPFQCTFE	acetylation	[2]
309	QLVHTGEKPFQCTFE	ubiquitination	[1, 2]
351	PFDVCNRKFAQSTNL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. 

Sequence Annotation

 ZN_FING 254 278 C2H2-type 1.
 ZN_FING 283 305 C2H2-type 2.
 ZN_FING 311 335 C2H2-type 3.
 ZN_FING 341 365 C2H2-type 4.
 REGION 32 102 Mediates transcriptional activation.
 REGION 237 372 Mediates transcriptional repression.  

Keyword

 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017114; TF_Yin_yang.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS