CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019906
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clathrin interactor 1 
Protein Synonyms/Alias
 Enthoprotin; Epsin-4; Epsin-related protein; EpsinR 
Gene Name
 Clint1 
Gene Synonyms/Alias
 Enth; Epn4; Epnr; Kiaa0171 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
208SAFPFSDKLGELSDKubiquitination[1]
473QNTDMVQKSASKTLPubiquitination[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). 
Sequence Annotation
 DOMAIN 24 157 ENTH.
 BINDING 37 37 Phosphatidylinositol lipid headgroup (By
 BINDING 75 75 Phosphatidylinositol lipid headgroup (By
 MOD_RES 171 171 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 253 253 Phosphoserine (By similarity).
 MOD_RES 307 307 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Lipid-binding; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 631 AA 
Protein Sequence
MLIFMYLYVC VCTCTCAFSL CSTNVVMNYS EIESKVREAT NDDPWGPSGQ LMGEIAKATF 60
MYEQFPELMN MLWSRMLKDN KKNWRRVYKS LLLLAYLIRN GSERVVTSAR EHIYDLRSLE 120
NYHFVDEHGK DQGINIRQKV KELVEFAQDD DRLREERKKA KKNKDKYVGV SSDSVGGFRY 180
NERYDPEPKS KWDEEWDKNK SAFPFSDKLG ELSDKIGSTI DDTISKFRRK DREDSPERCS 240
DSDEEKKARR GRSPKGEFKD EEETVTTKHI HITQATETTT TRHKRTANPS KTIDLGAAAH 300
YTGDKASPDQ NASTHTPQSS AKPSVPSSKS SGDLVDLFDG SSQSAGGSAD LFGGFADFGS 360
AAASGNFPSQ ATSGNGDFGD WSAFNQAPSG PVASGGELFG SAPQSAVELI SASQPALGPP 420
PAASNSADLF DLMGSSQATM TSSQSMNFSL MSTNTVGLGL PMSRSQNTDM VQKSASKTLP 480
STWSDPSVNI SLDNLLPGMQ PSKPQQPSLN TMIQQQNMQQ PLNVMTQSFG AVNLSSPSNM 540
LPVRPQTNPL LGGPMPMNMP GVMTGTMGMA PLGNSAGMSQ GMVGMNMNMG MSASGMGLSG 600
TMGMGMPSMA MPSGTVQPKQ DAFANFANFS K 631 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW. 
Interpro
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N.
 IPR001026; Epsin_dom_N. 
Pfam
 PF01417; ENTH 
SMART
 SM00273; ENTH 
PROSITE
 PS50942; ENTH 
PRINTS