UniProt Accession

 DSK2_YEAST; P48510; D6W0A3 

Genbank Protein ID

 L40587; Z49704; BK006946 

Genbank Nucleotide ID

 AAB07267.1; CAA89774.1; DAA10177.1 

Protein Name

 Ubiquitin domain-containing protein DSK2 

Protein Synonyms/Alias

  

Gene Name

 DSK2 

Gene Synonyms/Alias

 SHE4; YMR276W; YM8021.02 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
13	HIKSGQDKWEVNVAP	ubiquitination	[1, 2]
33	QFKEAINKANGIPVA	ubiquitination	[2]
49	QRLIYSGKILKDDQT	ubiquitination	[2]
52	IYSGKILKDDQTVES	acetylation	[3]
52	IYSGKILKDDQTVES	ubiquitination	[2]
76	HLVKSQPKPQTASAA	ubiquitination	[1, 2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway. 

Sequence Annotation

 DOMAIN 1 76 Ubiquitin-like.
 DOMAIN 327 371 UBA.  

Keyword

 3D-structure; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IC:SGD.
 GO:0030674; F:protein binding, bridging; IMP:SGD.
 GO:0030433; P:ER-associated protein catabolic process; IMP:SGD.
 GO:0007103; P:spindle pole body duplication associated with nuclear envelope; IGI:SGD. 

Interpro

 IPR006636; STI1_HS-bd.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR015496; Ubiquilin.
 IPR000626; Ubiquitin.
 IPR019954; Ubiquitin_CS.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF00627; UBA
 PF00240; ubiquitin 

SMART

 SM00727; STI1
 SM00165; UBA
 SM00213; UBQ 

PROSITE

 PS50030; UBA
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS