CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin A11 
Protein Synonyms/Alias
 Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50 
Gene Name
 Anxa11 
Gene Synonyms/Alias
 Anx11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
212EVLRKAMKGFGTDEQubiquitination[1]
250AYGKDLIKDLKSELSubiquitination[1]
269KTILALMKTPVLFDVubiquitination[1]
313RELSRAYKTEFQKTLubiquitination[1]
477EYKRMYGKSLYHDITacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner. 
Sequence Annotation
 REPEAT 207 267 Annexin 1.
 REPEAT 279 339 Annexin 2.
 REPEAT 363 423 Annexin 3.
 REPEAT 438 498 Annexin 4.
 MOD_RES 246 246 N6-acetyllysine (By similarity).
 MOD_RES 253 253 N6-acetyllysine (By similarity).
 MOD_RES 477 477 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MSYPGYPPPA GGYPPAAPGG GPWGGAGYPP PSMPPIGLDN VANYAGQFNQ DYLSGMAANM 60
SGTFGGANVP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP PYGMYPPPGG NPPPGMPSYP 120
AYPGAPVPGQ PMPPTGQQPP GAYPGQPPMT YPGQSPMPPP GQQPVPSYPG YSGSSTITPA 180
VPPAQFGNRG TITAASGFDP LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF 240
KTAYGKDLIK DLKSELSGNF EKTILALMKT PVLFDVYEIK EAIKGAGTDE ACLIEIFASR 300
SNEHIRELSR AYKTEFQKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV DMSLVQRDVQ 360
ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT GRDIEKSICR EMSGDLEQGM 420
LAVVKCLKNT PAFFAERLNK AMRGAGTKDR TLIRIMVSRS ELDLLDIRAE YKRMYGKSLY 480
HDITGDTSGD YRKILLKICG GND 503 
Gene Ontology
 GO:0042582; C:azurophil granule; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; IEA:Compara.
 GO:0042581; C:specific granule; IEA:Compara.
 GO:0005819; C:spindle; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:MGI.
 GO:0008429; F:phosphatidylethanolamine binding; IDA:MGI.
 GO:0044548; F:S100 protein binding; ISS:UniProtKB.
 GO:0007109; P:cytokinesis, completion of separation; ISS:UniProtKB.
 GO:0006909; P:phagocytosis; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR008157; AnnexinXI. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR01810; ANNEXINXI.