UniProt Accession

 SESD1_MOUSE; Q80UK0; Q3TLJ1; Q810W3; Q8CI09 

Genbank Protein ID

 AL772242; BC038005; BC044853; BC048358; AK166483 

Genbank Nucleotide ID

 CAM15773.1; AAH38005.1; AAH44853.1; AAH48358.1; BAE38801.1 

Protein Name

 SEC14 domain and spectrin repeat-containing protein 1 

Protein Synonyms/Alias

 Huntingtin-interacting protein-like protein 

Gene Name

 Sestd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
543	VLLEKHRKFVDVAQS	ubiquitination	[1]
677	EHIRDRMKLVSLKRQ	acetylation	[2, 3]
682	RMKLVSLKRQQLRHP	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity). 

Sequence Annotation

 DOMAIN 1 153 CRAL-TRIO.
 REPEAT 275 378 Spectrin 1.
 REPEAT 381 494 Spectrin 2.
 REPEAT 500 602 Spectrin 3.  

Keyword

 Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 696 AA 

Protein Sequence

Gene Ontology

 GO:0034704; C:calcium channel complex; IEA:Compara.
 GO:0070300; F:phosphatidic acid binding; IEA:Compara.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Compara.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Compara.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Compara.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0070273; F:phosphatidylinositol-4-phosphate binding; IEA:Compara.
 GO:0010314; F:phosphatidylinositol-5-phosphate binding; IEA:Compara. 

Interpro

 IPR001251; CRAL-TRIO_dom.
 IPR018159; Spectrin/alpha-actinin. 

Pfam

  

SMART

 SM00150; SPEC 

PROSITE

 PS50191; CRAL_TRIO 

PRINTS