| Tag | Content |
|---|
| CPLM ID | CPLM-023499 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
Protein Synonyms/Alias | Sam68-like mammalian protein 1; SLM-1; mSLM-1 |
Gene Name | Khdrbs2 |
Gene Synonyms/Alias | Slm1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 69 | ERVLIPVKQYPKFNF | ubiquitination | [1] | | 73 | IPVKQYPKFNFVGKL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity). Its phosphorylation by FYN inhibits its ability to regulate splice site selection (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer (By similarity). May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. |
Sequence Annotation | DOMAIN 65 135 KH. |
Keyword | Alternative splicing; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; SH3-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MGEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG KKEDEEKKYL DVISNKNIKL 60
SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS ILGKGSMRDK TKEEELRKSG 120
EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH ALEEIKKFLV PDYNDEIRQE QLRELSYLNG 180
SEESGRGRGI RGRGIRITPT APSRGRGGAV PPPPPPGRGV LTPRGTTVTR GALPVPPIAR 240
GVPTPRARGT AAVPGYRAPP PPAHDAYEEY GYDDGYGGEY DDQTYEAYDN SYVTPTQSVP 300
EYYDYGHGVN EDAYDSYAPE EWATTRSSLK APPPRSARGG YREHPYGRY 349 |
Gene Ontology | GO:0005634; C:nucleus; TAS:MGI. GO:0008143; F:poly(A) RNA binding; IDA:MGI. GO:0008266; F:poly(U) RNA binding; IDA:MGI. GO:0046982; F:protein heterodimerization activity; IDA:MGI. GO:0042169; F:SH2 domain binding; IDA:MGI. GO:0017124; F:SH3 domain binding; IDA:MGI. GO:0005070; F:SH3/SH2 adaptor activity; TAS:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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