CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040573
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 5'-3' exoribonuclease 1 
Protein Synonyms/Alias
  
Gene Name
 Xrn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
652KITRVDQKALYFCGFubiquitination[1]
736AVSDGETKFYIEEPPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1723 AA 
Protein Sequence
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 60
FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 120
TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 180
IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 240
PEETTFHLLH LSLMREYIDY EFSALKEKIT FKYDIEKIID DWILMGFLVG NDFIPHLPHL 300
HINHDALPLL YGTYIAILPE LGGYINESGH LNLPRFERYL VKLSDFDREH FSEVFVDLKW 360
FESKVGNKYL NEAAGAAAEE AKNCKEKRKP KGQENSLSWA ALDKSEGEGV ASRDNFEDET 420
EDDDLFETEF RQYKRTYYMT KMGVDVVSDE FLANQAACYV QAIQWILHYY YHGVQSWSWY 480
YPYHYAPFLS DIRSISTLKI HFELGKPFKP FEQLLAVLPS ASKNLLPTCY QHLMTSEDSP 540
IIEYYPPDFK TDLNGKQQEW EAVVLIPFID ETRLLEAMET CNHSLKKEER KRNQHSECLM 600
CWYDRDTEFT YSSPWPEKFP AIERCCTRYK MISLDAWRVD INKNKITRVD QKALYFCGFP 660
TLKHIKHKFF LKKSGVQVFQ QSSRGENLML EISVNAEPDE LRIENIASAV LGKAVFVNWP 720
HLEEARVVAV SDGETKFYIE EPPGTQKVYL GKTAPPSKVI QLTDKEQSNW TKEIQGISEQ 780
YLRRKGIIIN ETSAVVYAQL LTGRKYQISQ NGEVRLEKQW SKQILPFVYQ TIVKDIRAFD 840
SRFSNIKTLD DLFPPRTMVF MLGTPYYGCT GEVQDSGDLI TEGRIRVVFS IPCEPNLDAL 900
IQNQHKYSIK YNPGYVLAGR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 960
KKNEEVPGYT KKVGNEWMYS SAAEQLLAEY IERAPELFSY IAKNSQEDVF YEDDIWPGEN 1020
ENGAEKVQEI ITWLKGHPVS TLSRSSCDLH ILDAAIVEKI EEEVEKCKQR KSNKKVRVTV 1080
KPHLLYRPLE QQHGVIPDRD AEFRLFDRVV NVRESFSVPV GLRGTVIGIK GASREADVLF 1140
EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRCET GNQKLTAIVK PQPSVSHCSA 1200
APSGHLGGLN HSPQSPFLPT QVPTKGDDEF CNIWQSLQGA GKIQHLQPTV QEKGAVLPQE 1260
ISQVTEGHKS GFTDHSVRHQ QRKHDSQRKF KEEYKSPKAE CQSQKLSSKQ TSGGSARCSI 1320
KLLKRNESPG TSEAQKVVTS YPNAVHKPPS GIENFLASLN LSKENEAQLP HHGEPPDEAD 1380
LSPQSFAMKG TRMLKEILKI DSPDTRDSKN DMKKSDNEAT VSSRRDERGV SAHPKPSKKL 1440
TCHMNKPHGT NEFQNVASVD SVCWPGQMPP VSTPVTELSR ICSLVGMPQP DFSFLRTTQT 1500
MTVCQVKLSN GLLVHGPQCH SESEAKERAA LFALQQLGSL GVSFPLPPPI FTNYPPAVPP 1560
GAVPPVFTQP TANIMPSSSH LFGSVSWRPP VPVAGNAFHY PSYPGTMPLA GGVPGGVHSQ 1620
FIPLQVTKKR VANRKNFENK EAQSSQATPL QTNKPGSSEA TKMTPQESPP ASSSSSQAAQ 1680
PVSSHVETAS QGHVGSQPRS APSSSKRKSR KLAVNFSVSK PSE 1723 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0071044; P:histone mRNA catabolic process; IEA:Compara.
 GO:0071028; P:nuclear mRNA surveillance; IEA:Compara.
 GO:0016075; P:rRNA catabolic process; IEA:Compara. 
Interpro
 IPR027073; 5_3_exoribonuclease.
 IPR016494; 5_3_exoribonuclease_1.
 IPR004859; Put_53exo. 
Pfam
 PF03159; XRN_N 
SMART
  
PROSITE
  
PRINTS