UniProt Accession

 MTX2_HUMAN; O75431; A8JZZ4; Q53S50; Q53SQ2; Q5M7Z6 

Genbank Protein ID

 AF053551; AK289359; AC016739; AC073069; CH471058; BC067831; BC088359 

Genbank Nucleotide ID

 AAC25105.1; BAF82048.1; AAY14795.1; AAX93188.1; EAX11076.1; AAH67831.1; AAH88359.1 

Protein Name

 Metaxin-2 

Protein Synonyms/Alias

 Mitochondrial outer membrane import complex protein 2 

Gene Name

 MTX2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	GPIVQFVKAKGHSLS	ubiquitination	[1]
95	IVQFVKAKGHSLSDG	ubiquitination	[1, 2, 3]
108	DGLEEVQKAEMKAYM	ubiquitination	[2, 3]
177	KAIGWGKKTLDQVLE	ubiquitination	[3]
237	DELSEKVKNYSNLLA	ubiquitination	[3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in transport of proteins into the mitochondrion. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR019564; Sam37/metaxin. 

Pfam

 PF10568; Tom37 

SMART

  

PROSITE

  

PRINTS