UniProt Accession

 SUMO3_RAT; Q5XIF4 

Genbank Protein ID

 BC083728 

Genbank Nucleotide ID

 AAH83728.1 

Protein Name

 Small ubiquitin-related modifier 3 

Protein Synonyms/Alias

 SUMO-3 

Gene Name

 Sumo3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MSEEKPKEGVKT	acetylation	[1]
7	*MSEEKPKEGVKTEN	acetylation	[1]
11	EKPKEGVKTENDHIN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (By similarity). 

Sequence Annotation

 DOMAIN 15 92 Ubiquitin-like.
 CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 92 92 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Complete proteome; Cytoplasm; Isopeptide bond; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0019789; F:SUMO ligase activity; IEA:Compara.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IEA:Compara.
 GO:0016925; P:protein sumoylation; IEA:InterPro. 

Interpro

 IPR022617; SUMO.
 IPR027218; SUMO_chordates.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF11976; Rad60-SLD 

SMART

 SM00213; UBQ 

PROSITE

 PS50053; UBIQUITIN_2 

PRINTS