UniProt Accession

 COR1C_MOUSE; Q9WUM4; Q8VCQ5 

Genbank Protein ID

 AF143957; AK079327; AK082986; AK088101; BC019444; BC085498 

Genbank Nucleotide ID

 AAD32705.1; BAC37609.1; BAC38722.1; BAC40144.1; AAH19444.1; AAH85498.1 

Protein Name

 Coronin-1C 

Protein Synonyms/Alias

 Coronin-3 

Gene Name

 Coro1c 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
329	KRGLDVNKCEIARFF	acetylation	[1]
391	DPILISLKHGYIPGK	acetylation	[2]
413	KKNILDSKPAANKKS	acetylation	[2]
419	SKPAANKKSELSCAP	acetylation	[2]
419	SKPAANKKSELSCAP	succinylation	[2]
446	AKLDEILKEIKSIKE	acetylation	[1, 3]
464	SQDERISKLEQQLAK	acetylation	[1]
471	KLEQQLAKMAA****	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be involved in cytokinesis, motility, and signal transduction (By similarity). 

Sequence Annotation

 REPEAT 78 118 WD 1.
 REPEAT 128 168 WD 2.
 REPEAT 172 211 WD 3.
 REPEAT 263 303 WD 4.
 MOD_RES 301 301 Phosphotyrosine.
 MOD_RES 446 446 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 474 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IBA:RefGenome.
 GO:0051015; F:actin filament binding; IBA:RefGenome.
 GO:0000147; P:actin cortical patch assembly; TAS:MGI.
 GO:0006909; P:phagocytosis; TAS:MGI. 

Interpro

 IPR027333; CORO1C.
 IPR015505; Coronin.
 IPR015048; DUF1899.
 IPR015049; DUF1900.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF08953; DUF1899
 PF08954; DUF1900
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS