UniProt Accession

 KC1A_RAT; P97633; P97634 

Genbank Protein ID

 U77582; U77583 

Genbank Nucleotide ID

 AAB19227.1; AAB19228.1 

Protein Name

 Casein kinase I isoform alpha 

Protein Synonyms/Alias

 CKI-alpha; CK1 

Gene Name

 Csnk1a1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MASSSGSKAEFIVGG	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis. 

Sequence Annotation

 DOMAIN 17 285 Protein kinase.
 NP_BIND 23 31 ATP (By similarity).
 ACT_SITE 136 136 Proton acceptor (By similarity).
 BINDING 46 46 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Kinetochore; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0001948; F:glycoprotein binding; IDA:RGD.
 GO:0000287; F:magnesium ion binding; IDA:RGD.
 GO:0042277; F:peptide binding; IDA:RGD.
 GO:0051219; F:phosphoprotein binding; IDA:RGD.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS