| Tag | Content |
|---|
| CPLM ID | CPLM-022802 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Exportin-1 |
Protein Synonyms/Alias | Chromosome region maintenance 1 protein; Protein embargoed |
Gene Name | emb |
Gene Synonyms/Alias | Crm1; CG13387 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 666 | DIISRASKNVDFLKN | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Required for the function or maintenance of certain tissues such as brain and gut. Involved in the export of dl from the nucleus to the cytoplasm. |
Sequence Annotation | DOMAIN 43 109 Importin N-terminal. |
Keyword | Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Translocation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1063 AA |
Protein Sequence | MATMLTSDEA GKLLDFSQKL DINLLDKIVE VVYTAQGEQL RLAQSILTTL KEHPEAWTRV 60
DSILEYSQNQ RTKFYALQIL EEVIKTRWKV LPRNQCEGIK KYVVSLIIKT SSDPIVMEQN 120
KVYLNKLNMI LVHILKREWP RNWETFISDI VGASKTNESL CMNNMVILKN LSEEVFDFSQ 180
GQITQTKAKH LKDTMCSEFS QIFTLCSFVL ENSMNAALIH VTLETLLRFL NWIPLGYIFE 240
TQQIETLIFK FLSVPMFRNV TLKCLSEIAG LTAANYDENF ATLFKDTMVQ LEQIVGQNMN 300
MNHVFKHGSD TEQELVLNLA MFLCTFLKEH GKLVEDAKYV DYLNQALMYL VMISEVEDVE 360
VFKICLEYWN SLVEDLYNSE FFHPTLESTK RQQVYPRRRF YAPILSKVRF IMISRMAKPE 420
EVLVVENENG EVVREFMKDT NSINLYKNMR ETLVFLTHLD SVDTDRIMTL KLLNQVNGSE 480
FSWKNLNTLC WAIGSISGAF CEEDEKRFLV TVIKDLLGLC EQKKGKDNKA IIASNIMYVV 540
GQYPRFLRAH WKFLKTVVNK LFEFMHETHD GVQDMACDTF IKIAIKCRRY FVTIQPNEAC 600
TFIDEILTTM SSIICDLQPQ QVHTFYEAVG YMISAQVDQV QQDVLIERYM QLPNQVWDDI 660
ISRASKNVDF LKNMTAVKQL GSILKTNVAA CKALGHAYVI QLGRIYLDML NVYKITSENI 720
IQAIEVNGVN VNNQPLIKTM HVVKKETLNL ISEWVSRSND NQLVMDNFIP PLLDAILLDY 780
QRCKVPSARE PKVLSAMAII VHKLRQHITN EVPKIFDAVF ECTLDMINKN FEDFPQHRLS 840
FYELLQAVNA HCFKAFLNIP PAQFKLVFDS VVWAFKHTMR NVADMGLNIL FKMLQNLDQH 900
PGAAQSFYQT YFTDILMQIF SVVTDTSHTA GLPNHAIILA YMFSLVENRK ITVNLGPIPD 960
NMIFIQEYVA SLLKSAFTHL SDNQVKVFVT GLFNLDENVQ AFKEHLRDFL IQIREATGED 1020
DSDLYLEERE AALAEEQSNK HQMQRNIPGM LNPHELPEDM QDE 1063 |
Gene Ontology | GO:0031965; C:nuclear membrane; IDA:FlyBase. GO:0005643; C:nuclear pore; IMP:UniProtKB. GO:0008565; F:protein transporter activity; IDA:UniProtKB. GO:0007099; P:centriole replication; IMP:FlyBase. GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IDA:UniProtKB. GO:0006611; P:protein export from nucleus; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |