UniProt Accession

 SAHH2_ARATH; Q9LK36; Q8LPS8; Q944K5; Q949Z9 

Genbank Protein ID

 AP000377; CP002686; AY059888; AY093385; AY150471; AF428329; AY094404; AY050783 

Genbank Nucleotide ID

 BAB01858.1; AEE76817.1; AAL24370.1; AAM13384.1; AAN12996.1; AAL16259.1; AAM19782.1; AAK92718.1 

Protein Name

 Adenosylhomocysteinase 2 

Protein Synonyms/Alias

 AdoHcyase 2; S-adenosyl-L-homocysteine hydrolase 1; SAH hydrolase 2 

Gene Name

 SAHH2 

Gene Synonyms/Alias

 At3g23810; MYM9.16; MYM9_15 

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
15	TSSGREYKVKDMSQA	ubiquitination	[1]

Reference

 [1] Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants.
 Maor R, Jones A, Nühse TS, Studholme DJ, Peck SC, Shirasu K.
 Mol Cell Proteomics. 2007 Apr;6(4):601-10. [PMID: 17272265] 

Functional Description

 Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methinine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (By similarity). 

Sequence Annotation

 NP_BIND 206 208 NAD (By similarity).
 NP_BIND 269 274 NAD (By similarity).
 NP_BIND 348 350 NAD (By similarity).
 BINDING 64 64 Substrate (By similarity).
 BINDING 139 139 Substrate (By similarity).
 BINDING 205 205 Substrate (By similarity).
 BINDING 235 235 Substrate (By similarity).
 BINDING 239 239 Substrate (By similarity).
 BINDING 240 240 NAD (By similarity).
 BINDING 292 292 NAD (By similarity).
 BINDING 327 327 NAD (By similarity).
 BINDING 397 397 NAD (By similarity).
 MOD_RES 219 219 Phosphothreonine.
 CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Hydrolase; Isopeptide bond; NAD; One-carbon metabolism; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 485 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:TAIR.
 GO:0005886; C:plasma membrane; IDA:TAIR.
 GO:0005773; C:vacuole; IDA:TAIR.
 GO:0004013; F:adenosylhomocysteinase activity; IEA:EC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 

Pfam

 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 

SMART

 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 

PROSITE

 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 

PRINTS