CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Malignant T-cell-amplified sequence 1 
Protein Synonyms/Alias
 MCT-1; Multiple copies T-cell malignancies 1 
Gene Name
 Mcts1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19VSNCIQLKTSVIKGIubiquitination[1]
161EDIEKVNKGIGIENIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). 
Sequence Annotation
 DOMAIN 92 171 PUA.
 MOD_RES 81 81 Phosphothreonine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; DNA damage; Growth regulation; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 181 AA 
Protein Sequence
MGKGRFDEKE NVSNCIQLKT SVIKGIKNQL LEQFPGIEPW LNQIMPKKDP VKIVRCHEHI 60
EILTVNGELL FFRQREGPFY PTLRLLHKYP FILPHQQVDK GAIKFVLSGA NIMCPGLTSP 120
GAKLYPAAVD TIVAIMAEGK QHALCVGVMK MSAEDIEKVN KGIGIENIHY LNDGLWHMKT 180
YK 182 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002478; PUA.
 IPR015947; PUA-like_domain.
 IPR016437; Transl_RNA-bd_prd.
 IPR004521; Uncharacterised_CHP00451. 
Pfam
 PF01472; PUA 
SMART
 SM00359; PUA 
PROSITE
 PS50890; PUA 
PRINTS