| Tag | Content |
|---|
| CPLM ID | CPLM-004467 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase complex protein X component, mitochondrial |
Protein Synonyms/Alias | Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; Pyruvate dehydrogenase complex component E3BP |
Gene Name | PDX1 |
Gene Synonyms/Alias | YGR193C; G7579 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | KGGIVSWKYKVGEPF | acetylation | [1] | | 96 | ILKDEGSKDVDVGEP | acetylation | [1] | | 149 | EATQQHLKKATVTPI | acetylation | [1] | | 190 | ISKQKALKEIAPSGS | acetylation | [1] | | 212 | DVLAYLGKIPQDSVN | acetylation | [1] | | 237 | RLDLSNIKPIQLKPK | acetylation | [1] | | 242 | NIKPIQLKPKIAEQA | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
Sequence Annotation | DOMAIN 33 107 Lipoyl-binding.
MOD_RES 73 73 N6-lipoyllysine (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; Lipoyl; Mitochondrion; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 410 AA |
Protein Sequence | MLSAISKVST LKSCTRYLTK CNYHASAKLL AVKTFSMPAM SPTMEKGGIV SWKYKVGEPF 60
SAGDVILEVE TDKSQIDVEA LDDGKLAKIL KDEGSKDVDV GEPIAYIADV DDDLATIKLP 120
QEANTANAKS IEIKKPSADS TEATQQHLKK ATVTPIKTVD GSQANLEQTL LPSVSLLLAE 180
NNISKQKALK EIAPSGSNGR LLKGDVLAYL GKIPQDSVNK VTEFIKKNER LDLSNIKPIQ 240
LKPKIAEQAQ TKAADKPKIT PVEFEEQLVF HAPASIPFDK LSESLNSFMK EAYQFSHGTP 300
LMDTNSKYFD PIFEDLVTLS PREPRFKFSY DLMQIPKANN MQDTYGQEDI FDLLTGSDAT 360
ASSVRPVEKN LPEKNEYILA LNVSVNNKKF NDAEAKAKRF LDYVRELESF 410 |
Gene Ontology | GO:0005967; C:mitochondrial pyruvate dehydrogenase complex; IDA:SGD. GO:0005198; F:structural molecule activity; IDA:SGD. GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro. GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |