| Tag | Content |
|---|
| CPLM ID | CPLM-019343 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Germ cell-less protein-like 1 |
Protein Synonyms/Alias | |
Gene Name | GMCL1 |
Gene Synonyms/Alias | GCL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 387 | VGPQEINKEELEGNS | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). |
Sequence Annotation | DOMAIN 108 178 BTB.
MOTIF 49 55 Nuclear localization signal (Potential).
MOTIF 85 91 Nuclear localization signal (Potential). |
Keyword | Complete proteome; Developmental protein; Differentiation; Nucleus; Reference proteome; Spermatogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 515 AA |
Protein Sequence | MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH KRKRSSGSFC 60
YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT LFLNGENSDI KICALGEEWS 120
LHKIYLCQSG YFSSMFSGSW KESSMNIIEL EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR 180
VVAILAAACL LQLDGLIQQC GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL 240
MTHQNVELFK ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT 300
ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE QDAVVPSEWL 360
SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK LAKDGEYCWR WTGFNFGFDL 420
LVTYTNRYII FKRNTLNQPC SGSVSLQPRR SIAFRLRLAS FDSSGKLICS RTTGYQILTL 480
EKDQEQVVMN LDSRLLIFPL YICCNFLYIS PEKKN 515 |
Gene Ontology | GO:0005635; C:nuclear envelope; IEA:Compara. GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara. GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |