CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025063
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glyoxylate reductase/hydroxypyruvate reductase 
Protein Synonyms/Alias
  
Gene Name
 Grhpr 
Gene Synonyms/Alias
 mCG_2331 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
94HLALDEIKKRGIRVGubiquitination[1]
173QAIARRLKPFGVQRFubiquitination[1]
300HIGSATYKTRNTMSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Pyruvate. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV GAHGLLCRLS 60
DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV GYTPGVLTDA TAELAVSLLL 120
TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF 180
LYTGRQPRPQ EAAEFQAEFV PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF 240
INISRGDVVN QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 300
TRNTMSLLAA NNLLAGLRGE AMPSELKL 328 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0008465; F:glycerate dehydrogenase activity; IEA:Compara.
 GO:0030267; F:glyoxylate reductase (NADP) activity; IEA:Compara.
 GO:0016618; F:hydroxypyruvate reductase activity; IEA:Compara.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0007588; P:excretion; IEA:Compara.
 GO:0051259; P:protein oligomerization; IEA:Compara. 
Interpro
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 
SMART
  
PROSITE
 PS00671; D_2_HYDROXYACID_DH_3 
PRINTS