| Tag | Content |
|---|
| CPLM ID | CPLM-008191 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | YLP motif-containing protein 1 |
Protein Synonyms/Alias | Nuclear protein ZAP3; ZAP113 |
Gene Name | YLPM1 |
Gene Synonyms/Alias | C14orf170; ZAP3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 858 | SRGPGLVKQEDFRDK | sumoylation | [1] |
|
Reference | [1] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC. Mol Cell. 2010 Aug 27;39(4):641-52. [ PMID: 20797634] |
Functional Description | Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation (By similarity). |
Sequence Annotation | REGION 1901 1908 Involved in interaction with PPP1CA (By |
Keyword | Alternative splicing; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1951 AA |
Protein Sequence | MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ 60
LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ 120
QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS 180
QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS 240
KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 300
HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV 360
PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ 420
QIIQPPPHIQ ATTPPPGIPP PGVPQGIPPQ LTAAPVPPAS SSQSSQVPEK PRPALLPTPV 480
SFGSAPPTTY HPPLQSAGPS EQVNSKAPLS KSALPYSSFS SDQGLGESSA APSQPITAVK 540
DMPVRSGGLL PDPPRSSYLE SPRGPRFDGP RRFEDLGSRC EGPRPKGPRF EGNRPDGPRP 600
RYEGHPAEGT KSKWGMIPRG PASQFYITPS TSLSPRQSGP QWKGPKPAFG QQHQQQPKSQ 660
AEPLSGNKEP LADTSSNQQK NFKMQSAAFS IAADVKDVKA AQSNENLSDS QQEPPKSEVS 720
EGPVEPSNWD QNVQSMETQI DKAQAVTQPV PLANKPVPAQ STFPSKTGGM EGGTAVATSS 780
LTADNDFKPV GIGLPHSENN QDKGLPRPDN RDNRLEGNRG NSSSYRGPGQ SRMEDTRDKG 840
LVNRGRGQAI SRGPGLVKQE DFRDKMMGRR EDSREKMNRG EGSRDRGLVR PGSSREKVPG 900
GLQGSQDRGA AGSRERGPPR RAGSQERGPL RRAGSRERIP PRRAGSRERG PPRGPGSRER 960
GLGRSDFGRD RGPFRPEPGD GGEKMYPYHR DEPPRAPWNH GEERGHEEFP LDGRNAPMER 1020
ERLDDWDRER YWRECERDYQ DDTLELYNRE DRFSAPPSRS HDGDRRGPWW DDWERDQDMD 1080
EDYNREMERD MDRDVDRISR PMDMYDRSLD NEWDRDYGRP LDEQESQFRE RDIPSLPPLP 1140
PLPPLPPLDR YRDDRWREER NREHGYDRDF RDRGELRIRE YPERGDTWRE KRDYVPDRMD 1200
WERERLSDRW YPSDVDRHSP MAEHMPSSHH SSEMMGSDAS LDSDQGLGGV MVLSQRQHEI 1260
ILKAAQELKM LREQKEQLQK MKDFGSEPQM ADHLPPQESR LQNTSSRPGM YPPPGSYRPP 1320
PPMGKPPGSI VRPSAPPARS SVPVTRPPVP IPPPPPPPPL PPPPPVIKPQ TSAVEQERWD 1380
EDSFYGLWDT NDEQGLNSEF KSETAAIPSA PVLPPPPVHS SIPPPGPVPM GMPPMSKPPP 1440
VQQTVDYGHG RDISTNKVEQ IPYGERITLR PDPLPERSTF ETEHAGQRDR YDRERDREPY 1500
FDRQSNVIAD HRDFKRDRET HRDRDRDRGV IDYDRDRFDR ERRPRDDRAQ SYRDKKDHSS 1560
SRRGGFDRPS YDRKSDRPVY EGPSMFGGER RTYPEERMPL PAPSLSHQPP PAPRVEKKPE 1620
SKNVDDILKP PGRESRPERI VVIMRGLPGS GKTHVAKLIR DKEVEFGGPA PRVLSLDDYF 1680
ITEVEKEEKD PDSGKKVKKK VMEYEYEAEM EETYRTSMFK TFKKTLDDGF FPFIILDAIN 1740
DRVRHFDQFW SAAKTKGFEV YLAEMSADNQ TCGKRNIHGR KLKEINKMAD HWETAPRHMM 1800
RLDIRSLLQD AAIEEVEMED FDANIEEQKE EKKDAEEEES ELGYIPKSKW EMDTSEAKLD 1860
KLDGLRTGTK RKRDWEAIAS RMEDYLQLPD DYDTRASEPG KKRVRWADLE EKKDADRKRA 1920
IGFVVGQTDW EKITDESGHL AEKALNRTKY I 1951 |
Gene Ontology | GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara. GO:0032204; P:regulation of telomere maintenance; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |