CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM111B 
Protein Synonyms/Alias
 Cancer-associated nucleoprotein 
Gene Name
 FAM111B 
Gene Synonyms/Alias
 CANP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32VSKDTVMKQTHADTPubiquitination[1]
62KLKSEVNKHETALEMubiquitination[2, 3]
102SVFTAYGKPSESIYSubiquitination[4]
127RIKNQFNKNIIVYEEubiquitination[4]
148INLGMPLKCLPSDSHubiquitination[4]
167FGQRKSSKEDGHILRubiquitination[1]
227TIEGALCKDGRFRSDubiquitination[1, 4, 5, 6]
382AINLDVQKEAINLLKubiquitination[1, 2, 3, 4, 6, 7, 8]
429RMNLSPAKQFNIYKKubiquitination[1, 2, 3]
549NLDYAILKLKENGNAubiquitination[4]
585GHPEGQIKKIDGCTVubiquitination[4]
586HPEGQIKKIDGCTVIubiquitination[4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 734 AA 
Protein Sequence
MNSMKTEENK SFSAMEDDQR TRPEVSKDTV MKQTHADTPV DHCLSGIRKC SSTFKLKSEV 60
NKHETALEMQ NPNLNNKECC FTFTLNGNSR KLDRSVFTAY GKPSESIYSA LSANDYFSER 120
IKNQFNKNII VYEEKTIDGH INLGMPLKCL PSDSHFKITF GQRKSSKEDG HILRQCENPN 180
MECILFHVVA IGRTRKKIVK INELHEKGSK LCIYALKGET IEGALCKDGR FRSDIGEFEW 240
KLKEGHKKIY GKQSMVDEVS GKVLEMDISK KKALQQKDIH KKIKQNESAT DEINHQSLIQ 300
SKKKVHKPKK DGETKDVEHS REQILPPQDL SHYIKDKTRQ TIPRIRNYYF CSLPRKYRQI 360
NSQVRRRPHL GRRYAINLDV QKEAINLLKN YQTLNEAIMH QYPNFKEEAQ WVRKYFREEQ 420
KRMNLSPAKQ FNIYKKDFGK MTANSVSVAT CEQLTYYSKS VGFMQWDNNG NTGNATCFVF 480
NGGYIFTCRH VVHLMVGKNT HPSLWPDIIS KCAKVTFTYT EFCPTPDNWF SIEPWLKVSN 540
ENLDYAILKL KENGNAFPPG LWRQISPQPS TGLIYLIGHP EGQIKKIDGC TVIPLNERLK 600
KYPNDCQDGL VDLYDTTSNV YCMFTQRSFL SEVWNTHTLS YDTCFSDGSS GSPVFNASGK 660
LVALHTFGLF YQRGFNVHAL IEFGYSMDSI LCDIKKTNES LYKSLNDEKL ETYDEEKGKQ 720
ESSLQDHQIE PMEC 734 
Gene Ontology
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS