UniProt Accession

 TIM16_HUMAN; Q9Y3D7; Q6I9Z3; Q9H5X3 

Genbank Protein ID

 AF349455; AF151894; AK026514; CR457362; BC005024 

Genbank Nucleotide ID

 AAL57767.1; AAD34131.1; BAB15494.1; CAG33643.1; AAH05024.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit TIM16 

Protein Synonyms/Alias

 Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Presequence translocated-associated motor subunit PAM16 

Gene Name

 PAM16 

Gene Synonyms/Alias

 MAGMAS; TIM16; TIMM16; CGI-136 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	KNYEHLFKVNDKSVG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. 

Sequence Annotation

 REGION 58 110 J-like.  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Protein transport; Reference proteome; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 125 AA 

Protein Sequence

Gene Ontology

 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 

Interpro

 IPR005341; Tim16. 

Pfam

  

SMART

  

PROSITE

  

PRINTS