| Tag | Content |
|---|
| CPLM ID | CPLM-000633 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Afadin |
Protein Synonyms/Alias | Protein Af-6 |
Gene Name | Mllt4 |
Gene Synonyms/Alias | Af6 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1812 | QGQDVSDKVKASRKL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. |
Sequence Annotation | DOMAIN 39 133 Ras-associating 1.
DOMAIN 246 348 Ras-associating 2.
DOMAIN 441 507 FHA.
DOMAIN 668 915 Dilute.
DOMAIN 1014 1100 PDZ.
MOD_RES 216 216 Phosphoserine (By similarity).
MOD_RES 1114 1114 Phosphoserine (By similarity).
MOD_RES 1189 1189 Phosphoserine (By similarity).
MOD_RES 1239 1239 Phosphothreonine (By similarity).
MOD_RES 1282 1282 Phosphoserine (By similarity).
MOD_RES 1726 1726 Phosphoserine (By similarity).
MOD_RES 1804 1804 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell adhesion; Cell junction; Coiled coil; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1829 AA |
Protein Sequence | MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 60
RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 120
DREGRFVLKN ENDAIPAKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KREKEALRQA 180
SDKEERPSQG DDSENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS 240
DGRPDSGGTL RIYADSLKPN IPYKTILLST TDPADFAVAE SLEKYGLEKE NPKDYCIARV 300
MLPPGAQHSD ERGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDY IPKKMKKHVE 360
GKPLKGKDRA DGSGYGSALP PEKLPYLVEL SPGRRNHFAY YSYHTYEDGS DSRDKPKLYR 420
LQLSVTEVGT EKFDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRSMDAET YVDGQRISET 480
TMLQSGMRLQ FGTSHVFKFV DPIQDHVLSK RSVDGGLMVK GPRHKPGAVQ ETTFELGGDI 540
HSGTALPASR STTRLDSDRV SSASSTAERG MVKPMIRLDQ EQDYRRRESR TQDAAGPELM 600
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSSQH RPDISPTERT 660
HKAIAVVNKM VSMMEGVIQE VDQVDQKQKN IAGALAFWMA NASELLNFIK QDRDLSRITL 720
DAQDVLAHLV QMAFKYLVHC LQSELNNYMP AFLDDPEENS LQRPKIDDVL HTLTGAMSLL 780
RRCRVNAALT IQLFSQLFHF INMWLFNRLV TDPDSGLCSH YWGAIIRQQL GHIEAWAEKQ 840
GLELAADCHL SRIVQATTLL TMDKYVPDDI PNINSTCFKL NSLQLQALLQ NYHCAPDEPF 900
IPTDLIENVV AVAENTADEL ARSDGRDVQL EEDPDLQLPF LLPEDGYSCD VVRNIPNGLQ 960
EFLDPLCQRG FCRLVPHTRS PGTWTIYFEG ADYESHLMRE NTELTQPLRK EPEVITVTLK 1020
KQNGMGLSIV AAKGAGQDKL GIYVKSVVKG GAADVDGRLA AGDQLLSVDG RSLVGLSQER 1080
AAELMTRTSS VVTLEVAKQG AIYHGLATLL NQPSPMMQRI SDRRGSGKPR PKSEGFELYN 1140
NSAQNGSPES PQMPWTEYSE PKKLPGDDRL MKNRADHRSS PNVANQPPSP GGKSPYTSGT 1200
AAKITSVSTG NLCTEEQTPP PRPEAYPIPT QTYTREYFTF PASKSQDRMA PVQNQWPNYE 1260
EKPHMHTESD HASIAIQRVT RSQEELREEK VYQLERHRVE SGMDRKCDSD MWINQSSSVE 1320
SSTSSQEHLN HSSKSVTPAS TLTKSGPGRW KTPAAVLPTP VAVSQPIRTD LPPPPPPPPA 1380
HYTSDFDGIS MDLPLPPPPA NQAAPQSAQV AAAERKKREE HQRWYEKEKA RLEEERERKR 1440
REQERKLGQM RTQSLNPASF SPLATQAKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL 1500
QYITISKEEL SSGDSLSPDP WKRDAREKLE KQQQMHIVDM LSKEIHELQN KGDRTAEESD 1560
RLRKLMLEWQ FQKRLQESKQ KDEDDDEEED DDVDTMLIMQ RLEAERRARL QDEERRRQQQ 1620
LEEMRKREVE DRVRQEEDGR HQEEERVKRD AEEKRRQEEG YYSRLEAERR RQHEEAARRL 1680
LEPEEPGLSR PPLPQDYEPP SQSSAPSAPP PPPQRNASYL KTQVLSPDSL FTAKFVAYDD 1740
DDEEENYVPA GPNSYSGSAG TTAGTYDAPR DTREKLSRSQ DADLPGSSGA PENLTFRERQ 1800
RLFSQGQDVS DKVKASRKLT ELENELNTK 1829 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |