UniProt Accession

 SPY1_MOUSE; Q9QXV9 

Genbank Protein ID

 AF176903; BC053428; BC069914 

Genbank Nucleotide ID

 AAD56004.1; AAH53428.1; AAH69914.1 

Protein Name

 Protein sprouty homolog 1 

Protein Synonyms/Alias

 Spry-1 

Gene Name

 Spry1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
161	QLLVEDLKASLKEDP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. 

Sequence Annotation

 DOMAIN 177 289 SPR.  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0001656; P:metanephros development; IGI:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:MGI.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:MGI.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:MGI.
 GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IDA:MGI.
 GO:0034261; P:negative regulation of Ras GTPase activity; IDA:MGI.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:MGI.
 GO:0001759; P:organ induction; IMP:MGI.
 GO:0001657; P:ureteric bud development; IMP:MGI. 

Interpro

 IPR007875; Sprouty. 

Pfam

 PF05210; Sprouty 

SMART

  

PROSITE

 PS51227; SPR 

PRINTS