UniProt Accession

 ZFP42_HUMAN; Q96MM3; D3DP65; Q8WXE2 

Genbank Protein ID

 AF450454; AY429593; AK056719; AC108073; CH471056; CH471056; CH471056 

Genbank Nucleotide ID

 AAL47167.1; AAR07993.1; BAB71264.1; EAX04610.1; EAX04611.1; EAX04612.1 

Protein Name

 Zinc finger protein 42 homolog 

Protein Synonyms/Alias

 Zfp-42; Reduced expression protein 1; REX-1; hREX-1; Zinc finger protein 754 

Gene Name

 ZFP42 

Gene Synonyms/Alias

 REX1; ZNF754 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	FESLEYLKKGSEQQL	ubiquitination	[1]
134	VKKELPQKIVGENSL	ubiquitination	[2]
150	YSEYMTGKKLPPGGI	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). 

Sequence Annotation

 ZN_FING 188 212 C2H2-type 1.
 ZN_FING 217 239 C2H2-type 2.
 ZN_FING 245 269 C2H2-type 3.
 ZN_FING 275 299 C2H2-type 4.
 CROSSLNK 231 231 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 233 233 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008585; P:female gonad development; IEP:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0008584; P:male gonad development; IEP:UniProtKB.
 GO:0007126; P:meiosis; NAS:UniProtKB.
 GO:2000653; P:regulation of genetic imprinting; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS