UniProt Accession

 EVA1A_HUMAN; Q9H8M9; D6W5J3; Q9HC41 

Genbank Protein ID

 AK023453; AF177337; CR457314; AC007099; CH471053; CH471053; CH471053; CH471053; BC016157; BC063016 

Genbank Nucleotide ID

 BAB14580.1; AAG17981.1; CAG33595.1; AAY14774.1; EAW99591.1; EAW99592.1; EAW99593.1; EAW99594.1; AAH16157.1; AAH63016.1 

Protein Name

 Protein eva-1 homolog A 

Protein Synonyms/Alias

 Protein FAM176A; Transmembrane protein 166 

Gene Name

 EVA1A 

Gene Synonyms/Alias

 FAM176A; TMEM166; SP24 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	RFERTLNKNVFTSAE	ubiquitination	[1, 2, 3]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. 

Sequence Annotation

 REGION 1 60 Necessary for the localization and  

Keyword

 Apoptosis; Autophagy; Complete proteome; Endoplasmic reticulum; Lysosome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

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PRINTS