UniProt Accession

 D3Z1U3_MOUSE; D3Z1U3 

Genbank Protein ID

 AC163337 

Genbank Nucleotide ID

  

Protein Name

 4-hydroxyphenylpyruvate dioxygenase 

Protein Synonyms/Alias

  

Gene Name

 Hpd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	EVVSHVIKQGKIVFV	acetylation	[1]
24	EVVSHVIKQGKIVFV	ubiquitination	[2]
41	SALNPWNKEMGDHLV	ubiquitination	[2]
49	EMGDHLVKHGDGVKD	ubiquitination	[2]
55	VKHGDGVKDIAFEVE	ubiquitination	[2]
70	DCDHIVQKARERGAK	ubiquitination	[2]
77	KARERGAKIVREPWV	ubiquitination	[2]
88	EPWVEQDKFGKVKFA	acetylation	[1, 3, 4]
88	EPWVEQDKFGKVKFA	succinylation	[4]
88	EPWVEQDKFGKVKFA	ubiquitination	[2]
91	VEQDKFGKVKFAVLQ	ubiquitination	[2]
93	QDKFGKVKFAVLQTY	acetylation	[1, 3, 4]
93	QDKFGKVKFAVLQTY	succinylation	[4]
93	QDKFGKVKFAVLQTY	ubiquitination	[2]
110	TTHTLVEKINYTGRF	ubiquitination	[2]
127	GFEAPTYKDTLLPKL	acetylation	[4]
127	GFEAPTYKDTLLPKL	succinylation	[4]
127	GFEAPTYKDTLLPKL	ubiquitination	[2]
133	YKDTLLPKLPRCNLE	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:Compara.
 GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
 GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro. 

Interpro

 IPR005956; 4OHPhenylPyrv_dOase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS