| Tag | Content |
|---|
| CPLM ID | CPLM-016713 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/glucose cotransporter 1 |
Protein Synonyms/Alias | Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 |
Gene Name | Slc5a1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 623 | DKGPKMTKEEEEAMK | ubiquitination | [1] | | 630 | KEEEEAMKMKMTDTS | ubiquitination | [1] | | 632 | EEEAMKMKMTDTSEK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. |
Sequence Annotation | CARBOHYD 248 248 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Sugar transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 665 AA |
Protein Sequence | MDSSTLSPAV TATDAPIPSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST NRGTVGGFFL 60
AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG FEWNALVLVV VLGWIFVPIY 120
IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL LLYIFTKISA DIFSGAIFIN LALGLDIYLA 180
IFILLAITAL YTITGGLAAV IYTDTLQTAI MLVGSFILTG FAFNEVGGYE AFMDKYMKAI 240
PTKVSNGNFT AKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLAILALWY WCTDQVIVQR 300
CLSAKNMSHV KADCTLCGYL KLLPMFLMVM PGMISRILYT EKIACVLPEE CQKYCGTPVG 360
CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS ASTLFTMDIY TKIRKKASEK 420
ELMIAGRLFI LVLIGISIAW VPIVQSAQSG QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV 480
NEQGAFWGLI LGFLIGISRM ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFVISVIT 540
ILIISFLTKP IPDVHLYRWC WSLRNSKEER IDLDAGEEED IPEDSKDTIE IDTEAPQKKK 600
GCFRRAYDLF CGLDQDKGPK MTKEEEEAMK MKMTDTSEKP LWRTVVNING IILLAVAVFC 660
HAYFA 665 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0005903; C:brush border; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005355; F:glucose transmembrane transporter activity; IMP:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0050892; P:intestinal absorption; IDA:MGI. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |