CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ensconsin 
Protein Synonyms/Alias
 Epithelial microtubule-associated protein of 115 kDa; E-MAP-115; Microtubule-associated protein 7; MAP-7 
Gene Name
 MAP7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
107EKHLEERKKRLEEQRacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 203 203 Phosphoserine (By similarity).
 MOD_RES 209 209 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 231 231 Phosphothreonine.
 MOD_RES 254 254 Phosphoserine.
 MOD_RES 277 277 Phosphothreonine.
 MOD_RES 673 673 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 749 AA 
Protein Sequence
MAELGAGGDG HRGGDGAVRS ETAPDSYKVQ DKKNASSRPA SAISGQNNNH SGNKPDPPPV 60
LRVDDRQRLA RERREEREKQ LAAREIVWLE REERARQHYE KHLEERKKRL EEQRQKEERR 120
RAAVEEKRRQ RLEEDKERHE AVVRRTMERS QKPKQKHNRW SWGGSLHGSP SIHSADPDRR 180
SVSTMNLSKY VDPVISKRLS SSSATLLNSP DRARRLQLSP WESSVVNRLL TPTHSFLARS 240
KSTAALSGEA ASCSPIIMPY KAAHSRNSMD RPKLFVTPPE GSSRRRIIHG TASYKKERER 300
ENVLFLTSGT RRAVSPSNPK ARQPARSRLW LPSKSLPHLP GTPRPTSSLP PGSVKAAPAQ 360
VRPPSPGNIR PVKREVKVEP EKKDPEKEPQ KVANEPSLKG RAPLVKVEEA TVEERTPAEP 420
EVGPAAPAMA PAPASAPAPA SAPAPAPVPT PAMVSAPSST VNASASVKTS AGTTDPEEAT 480
RLLAEKRRLA REQREKEERE RREQEELERQ KREELAQRVA EERTTRREEE SRRLEAEQAR 540
EKEEQLQRQA EERALREREE AERAQRQKEE EARVREEAER VRQEREKHFQ REEQERLERK 600
KRLEEIMKRT RRTEATDKKT SDQRNGDIAK GALTGGTEVS ALPCTTNAPG NGKPVGSPHV 660
VTSHQSKVTV ESTPDLEKQP NENGVSVQNE NFEEIINLPI GSKPSRLDVT NSESPEIPLN 720
PILAFDDEGT LGPLPQVDGV QTQQTAEVI 749 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; TAS:ProtInc.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005102; F:receptor binding; ISS:BHF-UCL.
 GO:0005198; F:structural molecule activity; TAS:ProtInc.
 GO:0007163; P:establishment or maintenance of cell polarity; TAS:ProtInc.
 GO:0000226; P:microtubule cytoskeleton organization; TAS:ProtInc.
 GO:0072659; P:protein localization to plasma membrane; ISS:BHF-UCL.
 GO:0006970; P:response to osmotic stress; ISS:BHF-UCL. 
Interpro
 IPR008604; E-MAP-115. 
Pfam
 PF05672; MAP7 
SMART
  
PROSITE
  
PRINTS