CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 124 
Protein Synonyms/Alias
 Zinc finger protein HZF-16 
Gene Name
 ZNF124 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55NLASIGNKGEDQSIEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 13 106 KRAB.
 ZN_FING 122 144 C2H2-type 1.
 ZN_FING 150 172 C2H2-type 2.
 ZN_FING 178 200 C2H2-type 3.
 ZN_FING 206 228 C2H2-type 4.
 ZN_FING 234 256 C2H2-type 5.
 ZN_FING 262 284 C2H2-type 6.
 ZN_FING 290 312 C2H2-type 7.
 ZN_FING 318 340 C2H2-type 8.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA SIGNKGEDQS 60
IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ KTSLSVTRVH RDTVMHTGNG 120
HYGCTICEKV FNIPSSFQIH QRNHTGEKPY ECMECGKALG FSRSLNRHKR IHTGEKRYEC 180
KQCGKAFSRS SHLRDHERTH TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG 240
KAFSCLSSLQ GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR 300
CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK M 351 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS