UniProt Accession

 RAP1B_MOUSE; Q99JI6 

Genbank Protein ID

 BC033382; BC052480; M79314 

Genbank Nucleotide ID

 AAH33382.2; AAH52480.1; AAK14823.1 

Protein Name

 Ras-related protein Rap-1b 

Protein Synonyms/Alias

 GTP-binding protein smg p21B 

Gene Name

 Rap1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	PMILVGNKCDLEDER	ubiquitination	[1]
149	AFLESSAKSKINVNE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction (By similarity). 

Sequence Annotation

 NP_BIND 10 18 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 NP_BIND 147 149 GTP (By similarity).
 REGION 25 67 Interaction with KRIT1 (By similarity).
 MOTIF 32 40 Effector region (Probable).
 MOD_RES 39 39 ADP-ribosylserine; by botulinum toxin (By
 MOD_RES 179 179 Phosphoserine; by PKA (By similarity).
 MOD_RES 181 181 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-geranylgeranyl cysteine (By  

Keyword

 ADP-ribosylation; Cell junction; Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005911; C:cell-cell junction; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0008283; P:cell proliferation; IPI:MGI.
 GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.