CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription initiation factor IIA subunit 1 
Protein Synonyms/Alias
 General transcription factor IIA subunit 1; TFIIAL; Transcription initiation factor TFIIA 42 kDa subunit; TFIIA-42; Transcription initiation factor IIA alpha chain; TFIIA p35 subunit; Transcription initiation factor IIA beta chain; TFIIA p19 subunit 
Gene Name
 GTF2A1 
Gene Synonyms/Alias
 TF2A1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12ANTNTVPKLYRSVIEacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 280 280 Phosphoserine; by TAF1.
 MOD_RES 281 281 Phosphoserine; by TAF1.
 MOD_RES 316 316 Phosphoserine; by TAF1.
 MOD_RES 321 321 Phosphoserine; by TAF1.  
Keyword
 3D-structure; Acetylation; Alternative initiation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH 60
SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV 120
PDSKLIQHMN ASNMSAAATA ATLALPAGVT PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ 180
SVVLQQQVIP QMQPGGVQAP VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV 240
AAPTPAQAQI TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE 300
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK FHLKDGIMNL 360
NGRDYIFSKA IGDAEW 376 
Gene Ontology
 GO:0005672; C:transcription factor TFIIA complex; IDA:BHF-UCL.
 GO:0003677; F:DNA binding; IDA:BHF-UCL.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR009083; TFIIA_a-hlx.
 IPR004855; TFIIA_asu/bsu.
 IPR013028; TFIIA_asu_N.
 IPR009088; TFIIA_b-brl. 
Pfam
 PF03153; TFIIA 
SMART
  
PROSITE
  
PRINTS