CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014231
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-oxoglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase 
Gene Name
 Ogdh 
Gene Synonyms/Alias
 Kiaa4192 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1035AFDLDAFKKFS****ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). 
Sequence Annotation
 REGION 933 939 Recognized by alloreactive CD8 cytotoxic
 MOD_RES 970 970 N6-acetyllysine (By similarity).
 CROSSLNK 534 534 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Glycolysis; Isopeptide bond; Mitochondrion; Oxidoreductase; Reference proteome; Thiamine pyrophosphate; Transit peptide; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1023 AA 
Protein Sequence
MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE 60
MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV 120
DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLDLAVFKER 180
LRMLTVGGFY GLHESDLDKV FHLPTTTFIG GQEPALPLRE IIRRLEMAYC QHIGVEFMFI 240
NDLEQCQWIR QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV 300
LIPALKTIID MSSANGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS KLEAADEGSG 360
DMKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM GKTKAEQFYC GDTEGKKVMS 420
ILLHGDAAFA GQGIVYETFH LSDLPSYTTH GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA 480
RVVNAPIFHV NSDDPEAVMY VCKVAAEWRN TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL 540
MYKQIRKQKP VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFTRSKD EKILHIKHWL 600
DSPWPGFFTL DGQPRSMTCP STGLEEDVLF HIGKVASSVP VENFTIHGGL SRILKTRREL 660
VTNRTVDWAL AEYMAFGSLL KEGIHVRLSG QDVERGTFSH RHHVLHDQNV DKRTCIPMNH 720
LWPNQAPYTV CNSSLSEYGV LGFELGFAMA SPNALVLWEA QFGDFNNMAQ CIIDQFICPG 780
QAKWVRQNGI VLLLPHGMEG MGPEHSSARP ERFLQMCNDD PDVLPDLQEE NFDINQLYDC 840
NWIVVNCSTP GNFFHVLRRQ ILLPFRKPLI VFTPKSLLRH PEARTSFDEM LPGTHFQRVI 900
PENGPAAQDP HKVKRLLFCT GKVYYDLTRE RKARNMEEEV AITRIEQLSP FPFDLLLKEA 960
QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TIDRAKPVWY AGRDPAAAPA TGNKKTHLTE 1020
LQRFLDTAFD LDAFKKFS 1038 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
 GO:0045252; C:oxoglutarate dehydrogenase complex; IEA:Compara.
 GO:0034602; F:oxoglutarate dehydrogenase (NAD+) activity; IDA:MGI.
 GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; ISS:UniProtKB.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IEA:Compara.
 GO:0021695; P:cerebellar cortex development; IEP:UniProtKB.
 GO:0006091; P:generation of precursor metabolites and energy; ISS:UniProtKB.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0021766; P:hippocampus development; IEP:UniProtKB.
 GO:0006734; P:NADH metabolic process; IEA:Compara.
 GO:0061034; P:olfactory bulb mitral cell layer development; IEP:UniProtKB.
 GO:0021860; P:pyramidal neuron development; IEP:UniProtKB.
 GO:0021756; P:striatum development; IEP:UniProtKB.
 GO:0006104; P:succinyl-CoA metabolic process; IEA:Compara.
 GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IEP:UniProtKB.
 GO:0021794; P:thalamus development; IEP:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; IEA:Compara. 
Interpro
 IPR011603; 2oxoglutarate_DH_E1.
 IPR001017; DH_E1.
 IPR005475; Transketolase-like_Pyr-bd. 
Pfam
 PF00676; E1_dh
 PF02779; Transket_pyr 
SMART
 SM00861; Transket_pyr 
PROSITE
  
PRINTS