CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014467
UniProt Accession
Genbank Protein ID
 U41662 
Genbank Nucleotide ID
Protein Name
 Neuroligin-2 
Protein Synonyms/Alias
  
Gene Name
 Nlgn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
749ELVSLQLKRGGGVGAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. 
Sequence Annotation
 MOD_RES 714 714 Phosphoserine (By similarity).
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 136 136 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...) (Potential).
 DISULFID 106 141 By similarity.
 DISULFID 317 328 By similarity.
 DISULFID 487 521 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 836 AA 
Protein Sequence
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN 60
EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP 120
VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDSGKKPVM 180
LFLHGGSYME GTGNMFDGSV LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ 240
ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV 300
NYQPLKYTRL LAAKVGCDRE DSTEAVECLR RKSSRELVDQ DVQPARYHIA FGPVVDGDVV 360
PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY 420
PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF 480
YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN 540
FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF 600
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRTPGPGTSG TRRPPPPATL PPESDIDLGP 660
RAYDRFPGDS RDYSTELSVT VAVGASLLFL NILAFAALYY KRDRRQELRC RRLSPPGGSG 720
SGVPGGGPLL PTAGRELPPE EELVSLQLKR GGGVGADPAE ALRPACPPDY TLALRRAPDD 780
VPLLAPGALT LLPSGLGPPP PPPPPSLHPF GPFPPPPPTA TSHNNTLPHP HSTTRV 836 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0060077; C:inhibitory synapse; IDA:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL.
 GO:0042043; F:neurexin family protein binding; ISS:BHF-UCL.
 GO:0004872; F:receptor activity; IBA:RefGenome.
 GO:0097116; P:gephyrin clustering; ISS:BHF-UCL.
 GO:0007630; P:jump response; IMP:BHF-UCL.
 GO:0035641; P:locomotory exploration behavior; ISS:BHF-UCL.
 GO:0050885; P:neuromuscular process controlling balance; ISS:BHF-UCL.
 GO:0007158; P:neuron cell-cell adhesion; IDA:BHF-UCL.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.
 GO:0097151; P:positive regulation of inhibitory postsynaptic membrane potential; IMP:BHF-UCL.
 GO:0051965; P:positive regulation of synapse assembly; IDA:BHF-UCL.
 GO:0032230; P:positive regulation of synaptic transmission, GABAergic; ISS:BHF-UCL.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
 GO:0097119; P:postsynaptic density protein 95 clustering; ISS:BHF-UCL.
 GO:0097104; P:postsynaptic membrane assembly; ISS:BHF-UCL.
 GO:0097105; P:presynaptic membrane assembly; IDA:BHF-UCL.
 GO:0035418; P:protein localization to synapse; ISS:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:0019233; P:sensory perception of pain; ISS:BHF-UCL.
 GO:0035176; P:social behavior; IMP:BHF-UCL.
 GO:0072553; P:terminal button organization; IMP:BHF-UCL.
 GO:0001966; P:thigmotaxis; IMP:BHF-UCL. 
Interpro
 IPR002018; CarbesteraseB.
 IPR019819; Carboxylesterase_B_CS.
 IPR000460; Neuroligin. 
Pfam
 PF00135; COesterase 
SMART
  
PROSITE
 PS00941; CARBOXYLESTERASE_B_2 
PRINTS
 PR01090; NEUROLIGIN.