UniProt Accession

 MARE3_HUMAN; Q9UPY8; B7WPK5; O00265; Q6FHB0; Q6FI15; Q9BZP7; Q9BZP8 

Genbank Protein ID

 AB025186; AF288787; AF288787; CR536523; CR541845; AC013472; CH471053; CH471053; CH471053; CH471053; BC011557; Y11174 

Genbank Nucleotide ID

 BAA82958.1; AAK07556.1; AAK07557.1; CAG38760.1; CAG46643.1; AAY14653.1; EAX00660.1; EAX00662.1; EAX00663.1; EAX00666.1; AAH11557.1; CAA72060.1 

Protein Name

 Microtubule-associated protein RP/EB family member 3 

Protein Synonyms/Alias

 EB1 protein family member 3; EBF3; End-binding protein 3; EB3; RP3 

Gene Name

 MAPRE3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
229	ERDFYFSKLRDIELI	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). 

Sequence Annotation

 DOMAIN 14 116 CH.
 DOMAIN 194 264 EB1 C-terminal.
 REGION 217 281 DCTN1-binding.
 REGION 217 260 APC-binding.
 MOD_RES 161 161 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:BHF-UCL.
 GO:0005881; C:cytoplasmic microtubule; IDA:BHF-UCL.
 GO:0005874; C:microtubule; ISS:BHF-UCL.
 GO:0030496; C:midbody; ISS:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0008017; F:microtubule binding; ISS:BHF-UCL.
 GO:0005083; F:small GTPase regulator activity; NAS:UniProtKB.
 GO:0007049; P:cell cycle; ISS:BHF-UCL.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:BHF-UCL. 

Interpro

 IPR001715; CH-domain.
 IPR004953; EB1_C.
 IPR027328; MAPRE. 

Pfam

 PF00307; CH
 PF03271; EB1 

SMART

  

PROSITE

 PS50021; CH
 PS51230; EB1_C 

PRINTS