UniProt Accession

 GRPE_YEAST; P38523; D6W2T6 

Genbank Protein ID

 X78350; D26059; U09565; Z75140; BK006948 

Genbank Nucleotide ID

 CAA55145.1; BAA05058.1; AAA19253.1; CAA99452.1; DAA11002.1 

Protein Name

 GrpE protein homolog, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 MGE1 

Gene Synonyms/Alias

 GRPE; GRPE1; YGE1; YOR232W; O5099 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
54	EAKSEESKENNEDLT	acetylation	[1]
85	TKEASELKDRLLRSV	acetylation	[1]
116	AKDFALQKFAKDLLE	acetylation	[1]
144	EEDLQKSKEISDLYT	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0001405; C:presequence translocase-associated import motor; IDA:SGD.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IDA:SGD.
 GO:0030150; P:protein import into mitochondrial matrix; IMP:SGD.
 GO:0042026; P:protein refolding; IDA:SGD. 

Interpro

 IPR000740; GrpE.
 IPR013805; GrpE_coiled_coil.
 IPR009012; GrpE_head. 

Pfam

 PF01025; GrpE 

SMART

  

PROSITE

 PS01071; GRPE 

PRINTS

 PR00773; GRPEPROTEIN.