UniProt Accession

 TMOD3_HUMAN; Q9NYL9; B2R6G7; Q9NT43; Q9NZR0 

Genbank Protein ID

 AF237631; AF177171; AK312569; BC020542; AL137543 

Genbank Nucleotide ID

 AAF45299.1; AAF31670.1; BAG35464.1; AAH20542.1; CAB70801.1 

Protein Name

 Tropomodulin-3 

Protein Synonyms/Alias

 Ubiquitous tropomodulin; U-Tmod 

Gene Name

 TMOD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	RKDLEKYKDLDEDEL	ubiquitination	[1]
101	KGKIFIPKQKPVQTF	ubiquitination	[2]
103	KIFIPKQKPVQTFTE	ubiquitination	[2, 3]
172	SNVVKGEKILPVFDE	ubiquitination	[1, 2, 4, 5]
191	TNVEESLKRTKENDA	ubiquitination	[2]
217	NIPIPTLKDFAKALE	ubiquitination	[2]
230	LETNTHVKCFSLAAT	ubiquitination	[2]
252	TAFAEMLKVNKTLKS	ubiquitination	[2]
289	NETLAELKIDNQRQQ	ubiquitination	[2]
317	EENTNILKFGYQFTQ	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine.
 MOD_RES 71 71 Phosphoserine (By similarity).  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0005865; C:striated muscle thin filament; IEA:Compara.
 GO:0005523; F:tropomyosin binding; TAS:ProtInc. 

Interpro

 IPR004934; Tropomodulin. 

Pfam

 PF03250; Tropomodulin 

SMART

  

PROSITE

  

PRINTS