UniProt Accession

 PPLA_RAT; P61016; P20006 

Genbank Protein ID

 L03382; X71068; S95849; S95853 

Genbank Nucleotide ID

 AAA41849.1; CAA50394.1; AAN86727.1; AAB21903.1 

Protein Name

 Cardiac phospholamban 

Protein Synonyms/Alias

 PLB 

Gene Name

 Pln 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MEKVQYLTRS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 16 16 Phosphoserine; by PKA and DMPK (By
 MOD_RES 17 17 Phosphothreonine; by CaMK2 (By  

Keyword

 Acetylation; Complete proteome; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 52 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0016529; C:sarcoplasmic reticulum; IDA:RGD.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0042030; F:ATPase inhibitor activity; IDA:RGD.
 GO:0005246; F:calcium channel regulator activity; IEA:InterPro.
 GO:0086023; P:adrenergic receptor signaling pathway involved in heart process; IEA:Compara.
 GO:0006816; P:calcium ion transport; IMP:RGD.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0045822; P:negative regulation of heart contraction; IEA:Compara.
 GO:0090279; P:regulation of calcium ion import; IEA:Compara.
 GO:0051924; P:regulation of calcium ion transport; ISS:UniProtKB.
 GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Compara.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:1901077; P:regulation of relaxation of muscle; IEA:Compara.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0086092; P:regulation of the force of heart contraction by cardiac conduction; IEA:Compara. 

Interpro

 IPR005984; P_lamban. 

Pfam

 PF04272; Phospholamban 

SMART

  

PROSITE

  

PRINTS