CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039312
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Elongation factor 1-alpha 
Protein Synonyms/Alias
  
Gene Name
 LOC100360150 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
94LAYTLGVKQLIVGVNacetylation[1]
102QLIVGVNKMDSTEPPacetylation[1]
113TEPPYSQKRYEEIVKacetylation[1]
221RVETGVLKPGMVVTFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
WTTDLLHASE STTLSQNLQL WEETFFLTSS EYQCIENAGT TGHRDFIKNM ITGTSQADCA 60
VLIVAAGVGE FEAGISKNGQ TREHALLAYT LGVKQLIVGV NKMDSTEPPY SQKRYEEIVK 120
EVSTYIKKIG YNPDTVAFVP ISGWNGDNML EPSANMPWFK GWKVTRKDGS ASGTTLLEAL 180
DCILPPTRPT DKPLRLPLQD VYKIGGIGTV PVGRVETGVL KPGMVVTFAP VNVTTEVKSV 240
EMHHEALSEA LPGDNVGFNV KNVSVKDVRR DNVAGDSKND PPMEAAGFTA QVIILNHPGQ 300
ISAGYAPVLD CHTAHIACKF AELKEKIDRR SGKKLEAGPK FLKSGDAAIV DMVPGKPMCV 360
ESFSDYPPLG RFAVRDMRQT VAVGVIKAVD KKAAGAGKVT KSAQKAQKAK 410 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
  
PRINTS
 PR00315; ELONGATNFCT.