UniProt Accession

 RASK_RAT; P08644; P46203; P97914 

Genbank Protein ID

 U09793; AABR03032592; M12260; M12259; M54870; M16970 

Genbank Nucleotide ID

 AAB60458.1; AAA42011.1; AAA42011.1; AAA40937.1; AAA41494.1 

Protein Name

 GTPase KRas 

Protein Synonyms/Alias

 K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase KRas, N-terminally processed 

Gene Name

 Kras 

Gene Synonyms/Alias

 Kras2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
42	TIEDSYRKQVVIDGE	methylation	[1]

Reference

 [1] A method for the comprehensive proteomic analysis of membrane proteins.
 Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd.
 Nat Biotechnol. 2003 May;21(5):532-8. [PMID: 12692561] 

Functional Description

 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 10 17 GTP.
 NP_BIND 57 61 GTP.
 NP_BIND 116 119 GTP.
 REGION 166 185 Hypervariable region.
 MOTIF 32 40 Effector region.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in GTPase KRas, N-
 MOD_RES 104 104 N6-acetyllysine (By similarity).
 MOD_RES 186 186 Cysteine methyl ester; in isoform 2A (By
 LIPID 180 180 S-palmitoyl cysteine (By similarity).
 LIPID 186 186 S-farnesyl cysteine; in isoform 2A (By  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Proto-oncogene; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0019003; F:GDP binding; IDA:RGD.
 GO:0019002; F:GMP binding; IDA:RGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0030275; F:LRR domain binding; IDA:RGD.
 GO:0019221; P:cytokine-mediated signaling pathway; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IMP:RGD.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:RGD.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IMP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0051385; P:response to mineralocorticoid stimulus; IEP:RGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0035176; P:social behavior; IEP:RGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.