CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024117
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit beta-1 
Protein Synonyms/Alias
 Adapter-related protein complex 3 subunit beta-1; Adaptor protein complex AP-3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain 
Gene Name
 Ap3b1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74VGMIAKGKNASELFPacetylation[1]
125STFQRALKDPNQLIRacetylation[2]
513ENCERVPKIAPDVLRubiquitination[3]
550KLYLTNSKQTKLLTQubiquitination[3]
587QLIVPNEKSGALSKYubiquitination[3]
603KKIFLAPKPAPLLESubiquitination[3]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
Sequence Annotation
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 610 610 Phosphoserine (By similarity).
 MOD_RES 761 761 Phosphoserine (By similarity).
 MOD_RES 763 763 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasmic vesicle; Endocytosis; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1105 AA 
Protein Sequence
MSSNSFAYNE QSGGGEAAEL GQEATSTISP SGAFGLFSSD WKKNEDLKQM LESNKDSAKL 60
DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV YLVRYAEEQQ DLALLSISTF 120
QRALKDPNQL IRASALRVLS SIRVPIIVPV MMLAIKEASA DLSPYVRKNA AHAIQKLYSL 180
DPEQKEMLIE VIEKLLKDKS TLVAGSVVMA FEEVCPDRID LIHRNYRKLC NLLVDVEEWG 240
QVVIIHMLTR YARTQFVSPW REDGGLEDNE KNFYESEEEE EEKEKSSRKK SYAMDPDHRL 300
LIRNTKPLLQ SRNAAVVMAV AQLYWHISPK SEAGVISKSL VRLLRSNREV QYIVLQNIAT 360
MSIERKGMFE PYLKSFYVRS TDPTMIKTLK LEILTNLANE ANISTLLREF QTYVRSQDKQ 420
FAAATIQTIG RCATSISEVT DTCLNGLVCL LSNRDEIVVA ESVVVIKKLL QMQPAQHGEI 480
IRHMAKLLDS ITVPVARASI LWLIGENCER VPKIAPDVLR KMAKSFTSED DLVKLQILNL 540
AAKLYLTNSK QTKLLTQYIL NLGKYDQNYD IRDRTRFIRQ LIVPNEKSGA LSKYAKKIFL 600
APKPAPLLES PFKDRDRFQL GTLSHTLNIK ASGYLELSNW PEVAPDPSVR NVEVIESAKE 660
WTPLGKTKKE KPMKKFYSES EEEEDEDEDE DEEEEEKEDE DENPSDSSSD SESGSGSESG 720
DTGTEDSSED SSSGQDSETG SQAEAERQKV AKRNSKTKRK SDSENREKKN ENSKASESSS 780
EESSSMEDSS SESESESGSD SEPAPRNVAP AKERKPQQER HPPSKDVFLL DLDDFNPVST 840
PVALPTPALS PSLIADLEGL NLSTSSSVIN VSTPVFVPTK THELLHRMHG KGLAAHYCFP 900
RQPCIFSDKM VSVQITLTNT SDRKIENIHI GGKGLPVGMQ MHAFHPIDSL EPKGSVTVSV 960
GIDFCDSTQT ASFQLCTKDD CFNVTLQPPV GELLSPVAMS EKDFKKEQGT LTGMNETSAT 1020
LIAAPQNFTP SMILQKVVNV ANLGAVPSSQ DNVHRFAART VHSGSLMLVT VELKEGSTAQ 1080
LIINTEKTVI GSVLLRELKP VLSQG 1105 
Gene Ontology
 GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; TAS:MGI.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IMP:MGI.
 GO:0007596; P:blood coagulation; IMP:MGI.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0032438; P:melanosome organization; IEA:Compara.
 GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI.
 GO:0006622; P:protein targeting to lysosome; IMP:MGI.
 GO:0006829; P:zinc ion transport; TAS:BHF-UCL. 
Interpro
 IPR026740; AP3_beta.
 IPR026739; AP_beta.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N. 
Pfam
 PF01602; Adaptin_N 
SMART
  
PROSITE
  
PRINTS