UniProt Accession

 HNRPF_RAT; Q794E4 

Genbank Protein ID

 AB022209; BC097275; BC103634 

Genbank Nucleotide ID

 BAA37095.1; AAH97275.1; AAI03635.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein F 

Protein Synonyms/Alias

 hnRNP F; Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 

Gene Name

 Hnrnpf 

Gene Synonyms/Alias

 Hnrpf 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
14	GGEGYVVKLRGLPWS	acetylation	[1]
87	HRYIEVFKSHRTEMD	acetylation	[1]
224	RRYIGIVKQAGLDRM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). 

Sequence Annotation

 DOMAIN 11 90 RRM 1.
 DOMAIN 111 188 RRM 2.
 DOMAIN 289 366 RRM 3.
 REGION 81 86 Interaction with RNA (By similarity).
 REGION 179 184 Interaction with RNA (By similarity).
 REGION 355 360 Interaction with RNA (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylmethionine; in Heterogeneous
 MOD_RES 104 104 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 224 224 N6-acetyllysine (By similarity).
 CROSSLNK 72 72 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003727; F:single-stranded RNA binding; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR012996; Znf_CHHC. 

Pfam

 PF08080; zf-RNPHF 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS