| Tag | Content |
|---|
| CPLM ID | CPLM-044319 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Methylthioribulose-1-phosphate dehydratase |
Protein Synonyms/Alias | MTRu-1-P dehydratase; APAF1-interacting protein |
Gene Name | APIP |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 82 | IAPSGVQKERIQPED | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity). |
Sequence Annotation | METAL 132 132 Zinc (By similarity).
METAL 134 134 Zinc (By similarity). |
Keyword | Amino-acid biosynthesis; Apoptosis; Complete proteome; Cytoplasm; Lyase; Metal-binding; Methionine biosynthesis; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 259 AA |
Protein Sequence | MRRAVAYMAI KIEVQGHQSF AIPSGTFWLW RSLLSQDKEH PRYLIPELCK QFYHLGWVTG 60
TGGGISLKHG DEIYIAPSGV QKERIQPEDM FVCDINEKDI SGPSPSKKLK KSQCTPLFMN 120
AYTMRGAGAV IHTHSKAAVM ATLLFPGREF KITHQEMIKG IKKCTSGGYY RYDDMLVVPI 180
IENTPEEKDL KDRMAHAMNE YPDSCAVLVR RHGVYVWGET WEKAKTMCEC YDYLFDIAVS 240
MKKVGLDPSQ LPVGENGIV 259 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0046570; F:methylthioribulose 1-phosphate dehydratase activity; IEA:HAMAP. GO:0008270; F:zinc ion binding; IEA:HAMAP. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0019284; P:L-methionine biosynthetic process from S-adenosylmethionine; IEA:HAMAP. GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |