CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019470
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Conserved oligomeric Golgi complex subunit 8 
Protein Synonyms/Alias
 COG complex subunit 8; Component of oligomeric Golgi complex 8 
Gene Name
 COG8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88DLAFANYKTFIRGAEubiquitination[1, 2, 3]
130QSCRNFVKEAEEISSubiquitination[1, 3]
246TEAELRVKFLQARDAubiquitination[3]
273DPYFHITKTIEASRVubiquitination[1, 3]
381VAISTFQKAIQETVEubiquitination[1]
558PLAFILPKRETLFTLubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Required for normal Golgi function (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 612 AA 
Protein Sequence
MATAATIPSV ATATAAALGE VEDEGLLASL FRDRFPEAQW RERPDVGRYL RELSGSGLER 60
LRREPERLAE ERAQLLQQTR DLAFANYKTF IRGAECTERI HRLFGDVEAS LGRLLDRLPS 120
FQQSCRNFVK EAEEISSNRR MNSLTLNRHT EILEILEIPQ LMDTCVRNSY YEEALELAAY 180
VRRLERKYSS IPVIQGIVNE VRQSMQLMLS QLIQQLRTNI QLPACLRVIG YLRRMDVFTE 240
AELRVKFLQA RDAWLRSILT AIPNDDPYFH ITKTIEASRV HLFDIITQYR AIFSDEDPLL 300
PPAMGEHTVN ESAIFHGWVL QKVSQFLQVL ETDLYRGIGG HLDSLLGQCM YFGLSFSRVG 360
ADFRGQLAPV FQRVAISTFQ KAIQETVEKF QEEMNSYMLI SAPAILGTSN MPAAVPATQP 420
GTLQPPMVLL DFPPLACFLN NILVAFNDLR LCCPVALAQD VTGALEDALA KVTKIILAFH 480
RAEEAAFSSG EQELFVQFCT VFLEDLVPYL NRCLQVLFPP AQIAQTLGIP PTQLSKYGNL 540
GHVNIGAIQE PLAFILPKRE TLFTLDDQAL GPELTAPAPE PPAEEPRLEP AGPACPEGGR 600
AETQAEPPSV GP 612 
Gene Ontology
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR007255; COG8.
 IPR016632; COG8_Metazoal_Plant.
 IPR016159; Cullin_repeat-like_dom. 
Pfam
 PF04124; Dor1 
SMART
  
PROSITE
  
PRINTS