CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 4B1 
Protein Synonyms/Alias
 CYPIVB1; Cytochrome P450 L-2; Cytochrome P450 isozyme 5 
Gene Name
 Cyp4b1 
Gene Synonyms/Alias
 Cyp4b-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
133LLVLDGPKWFQHRKLacetylation[1]
167STRMMLDKWEKKASEacetylation[1]
389QVYRQLNKPVTFVDGacetylation[1]
482EFSLDPSKMPIKVPQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 453 453 Iron (heme axial ligand) (By similarity).
 BINDING 315 315 Heme (covalent; via 1 link) (By  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 511 AA 
Protein Sequence
MVLNFLSPSL SRLGLWASVV ILMVIVLKLF SLLLRRQKLA RAMDSFPGPP THWLFGHALE 60
IQKLGSLDKV VSWAQQFPHA HPLWFGQFVG FLNIYEPDYA KAVYSRGDPK AADVYDFFLQ 120
WIGKGLLVLD GPKWFQHRKL LTPGFHYDVL KPYVAIFAES TRMMLDKWEK KASENKSFDI 180
FCDVGHMALD TLMKCTFGKG DSGLGHRDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT 240
PHGRRFLRAC KIAHDHTDEV IRQRKAALQD EKERKKIQQR RHLDFLDILL GVRDESGIKL 300
SDAELRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQQL CREEVRGILG DQDSFQWDDL 360
AKMTYLTMCM KECFRLYPPV PQVYRQLNKP VTFVDGRSLP AGSLISLHIY ALHRNSTVWP 420
DPEVFDPLRF SPENAAGRHP FAFMPFSAGP RNCIGQQFAM NEMKVVTALC LLRFEFSLDP 480
SKMPIKVPQL ILRSKNGIHL YLKPLASRSG K 511 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0018585; F:fluorene oxygenase activity; IDA:RGD.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:RGD.
 GO:0018879; P:biphenyl metabolic process; IMP:RGD.
 GO:0042738; P:exogenous drug catabolic process; IDA:RGD.
 GO:0018917; P:fluorene metabolic process; IDA:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.